Are booster shots necessary? Study compares vaccines against COVID-19 with natural immunity

Amid much debate over the need for a booster dose to curb COVID infections and reinfection, a new study reveals that immunity to the SARS-CoV-2 virus from vaccination is temporary and depends on an individual’s antibody levels.

Therefore, in order to protect ourselves from infection, our body needs the latest boosters with vaccines that are well prepared to respond to changes in the evolving virus.

In a study published in the journal Proceedings of the National Academy of Sciences (PNAS) June 15, a study using comparative evolutionary analysis explained how vaccines produce longer-lasting immunity than antibodies against infection, necessitating revaccination.

Using comparative evolutionary analysis, study author Jeffrey P Townsend and colleagues assessed the persistence of immunity and the probability of breakthrough infections over time.

A comparative analysis of vaccine-induced and natural immunity

The study examined differences in the duration of immunity to SARS-CoV-2 from vaccines compared to natural infection based on attenuated antibody levels. A subsequent analysis of the study included trends in IgG levels of antibodies to spike proteins over time after vaccination with four common SARS-CoV-2 vaccines. news agency ANI.

The authors used coronavirus affinity to integrate long-term immunological data from endemic coronavirus infections, reinfection data from close human relatives infected with SARS-CoV-2, declining antibody levels after natural infection with zoonotic coronaviruses, and immunological data after SARS. – Vaccination against CoV-2 has been reported ANI.

While natural infection provided an average of 21.5 months of protection against breakthrough infection, the mRNA vaccines produced by Pfizer-BioNTech and Moderna produced higher levels of antibodies than natural infection, resulting in a time to breakthrough infection of 29.6 months.

The authors found that the virus-vectored vaccines produced by Oxford-AstraZeneca and Johnson & Johnson/Janssen produced antibody levels similar to those produced by natural infection, with a mean time to breakthrough infection of 22.4 months and 20.5 months, respectively.

The results of the study indicated the need for revaccination to reduce breakthrough infections and reinfections.

Godfrey Kemp

"Bacon fanatic. Social media enthusiast. Music practitioner. Internet scholar. Incurable travel advocate. Wannabe web junkie. Coffeeaholic. Alcohol fanatic."

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